Prof. Ge Zhang
B. Med Shanghai University of Chinese Medicine, Shanghai, China
M. Med. Institute of Orthopaedics & Traumatology, Shanghai University of Chinese
M.D. Institute of Orthopaedics & Traumatology, Shanghai University Medicine & Department
of Orthopaedics & Traumatology, The Chinese University of Hong Kong
Previous academic positions held:
1995.8-2000.11 Resident Institute of Orthopaedics & Traumatology, Shu Guang Hospital, Shanghai University of Chinese Medicine
2000.12-2004.2 Physician-in-Charge Institute of Orthopaedics & Traumatology, Shu Guang Hospital, Shanghai University of Chinese Medicine
2004.3-2007.6 Postdoctoral Research Fellow Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong
2007.7-2012.8 Research Assistant Professor Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong
Present academic position:
2012.9- Associate Professor Ge Zhang’s Lab (www.gezhanglab.com), Institute for Advancing Translational Medicine in Bone & Joint Diseases, Hong Kong Baptist University & Teaching Division, School of Chinese Medicine, Hong Kong Baptist University
Previous relevant research work:
Technical expertise Bone bio-imaging, Bone histomorphometry, Bone biology, Bone biomechanics Research area Molecular understandings and RNAi-based & phytotherapy-based translational research in osteoporosis, osteonecrosis, osteoarthritis, rheumatoid arthritis and facture repair
3 Theses; 9 Book Chapters; 106 SCI Papers; Sum of the Times cited (excluding self-citation): 220; h-index: 9
Ten Representative publications in the past ten years:
1. Wang X, Guo B, …, Zhang G (Corresponding Author), Li Y (Corresponding Author). miR-214 targets ATF4 to
inhibit bone formation. Nat Med. 2013 Jan;19(1):93-100
2. Zhang G (Corresponding Author), Guo B, Wu H, Tang T, Zhang BT, …, Zhang L (Corresponding Author), Qin L
(Corresponding Author). A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic
therapy. Nat Med. 2012 Jan 29;18(2):307-14
3. Xie XH, Wang XL, He YX, Liu Z, Sheng H, Zhang G (Corresponding Author), Qin L (Corresponding Author).
Promotion of bone repair by implantation of cryopreserved bone marrow-derived mononuclear cells in a rabbit
model of steroid-associated osteonecrosis. Arthritis Rheum. 2012 May;64(5):1562-71
4. He YX, Liu Z, Pan XH, Tang T, Guo BS, Zheng LZ, Xie XH, Wang XL, Lee KM, Li G, Cao YP, Wei L, Chen Y, Yang
ZJ, Hung LK, Qin L, Zhang G (Corresponding Author). Deletion of estrogen receptor beta accelerates early
stage of bone healing in a mouse osteotomy model. Osteoporosis Int. 2012 Jan;23(1):377-89.
5. Zhang G, Sheng H, et al. Continuous occurrence of both insufficient neovascularization and elevated vascular
permeability in rabbit proximal femur during inadequate repair of steroid-associated osteonecrotic lesions.
Arthritis Rheum. 2009 Oct;60(10):2966-77.
6. Zhang G, Wang XL, Sheng H, et al. Constitutional flavonoids derived from Epimedium dose-dependently
reduce incidence of steroid-associated osteonecrosis not via direct action by themselves on potential cellular
targets. PlosOne 2009; 4: e6419
7. Zhang G, Qin L, et al. A Novel Semisynthesized Small Molecule Icaritin Reduces Incidence of
Steroid-associated Osteonecrosis with Inhibition of both Thrombosis and Lipid-deposition in a Dose-dependent
Manner. Bone 2009; 44: 345-56
8. Zhang G, Qin L, Shi Y. Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone
loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. J Bone
Miner Res. 2007 Jul;22(7):1072-9.
9. Zhang G, Qin L, et al. Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced
osteoporosis in rats independent of its enhancement in intestinal calcium absorption. Bone. 2006
10.Zhang G (Corresponding Author), et al. A comparative study between axial compression and lateral fall
configuration tested in a rat proximal femur model. Clin Biomech (Bristol, Avon). 2005 Aug;20(7):729-35.